|
Hepatitis B
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In vitro IFN-λ1 treatment of Hep3B and Huh7 human hepatoma cell lines increased MHC class I expression, activated JAK-STAT signaling pathways, induced IFN-stimulated gene expression, and inhibited hepatitis B surface antigen (HBsAg) expression.
|
24769671 |
2014 |
|
Hepatitis B
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We confirmed in two independent studies that the combination of HBsAg and HBV DNA levels at week 12 identifies HBeAg-negative patients with a very low chance of SR to either 48 or 96 weeks of PEG-IFN therapy.
|
22245886 |
2012 |
|
Hepatitis B
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Knockdown of FN expression significantly inhibited HBV DNA replication and protein synthesis through activating endogenous IFN-α production.
|
27023403 |
2016 |
|
Hepatitis B
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These IFN-alphas have an activity profile that may result in an improved therapeutic index and, consequently, better clinical efficacy for the treatment of chronic viral diseases such as hepatitis B virus, human papilloma virus, HIV, or chronic hepatitis C.
|
17494769 |
2007 |
|
Hepatitis B
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We measured the frequencies of circulating myeloid (mDC) and plasmacytoid (pDC) dendritic cells and IFN-α production along with the expression of DC-SIGN and Toll Like Receptors (TLR's) in HBV patients at different time points.
|
27658394 |
2016 |
|
Hepatitis B
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We found a significant (P < 0.01) correlation between the HBV DNA levels at midtreatment and response to IFN therapy.
|
9658370 |
1998 |
|
Hepatitis B
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Defining an "immediate virological response (IVR)" as the loss of serum hepatitis C virus (HCV) RNA 7 d after the first administration of PEG-IFN alpha, we conducted a 12-wk course of PEG-IFN alpha2a monotherapy without the addition of ribavirin for 38 patients who had low pretreatment HCV RNA load and exhibited IVR.
|
20333792 |
2010 |
|
Hepatitis B
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
His serum hepatitis C virus (HCV) RNA level became undetectable 1 week after the initiation of peg-IFN-alpha2b plus ribavirin treatment.
|
17287904 |
2006 |
|
Hepatitis B
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Based on these results, precore mutants do respond to IFN, and therefore, IFN is indicated in patients with HBeAb, especially those with low serum HBV DNA levels.
|
8745316 |
1995 |
|
Hepatitis B
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The largest reduction was observed in mice given NVR3-778 + peg-IFN; in all mice in this group, the serum level of HBV DNA was below the limit of quantification.
|
29079518 |
2018 |
|
Hepatitis B
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Inhibition of miR-3613-3p decreased relative expressions of IFN-α and IFN-β, HBV DNA copies, and increased the hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) levels, whereas miR-3613-3p overexpression reversed these changes in vitro and in vivo.
|
31201869 |
2019 |
|
Hepatitis B
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
No significant differences were observed among groups for HBeAg seroconversion (PEG-IFN alfa-2a+placebo, 36.3%; PEG-IFN alfa-2a+ETV, 29.5%; and PEG-IFN alfa-2a+ADV, 27.4%), HBeAg loss (37.4%, 32.2%, and 28.6%, respectively) or change in hepatitis B surface antigen (HBsAg) levels from baseline (-0.56 IU/mL, -0.60 IU/mL, and -0.41 IU/mL, respectively).
|
29456079 |
2018 |
|
Hepatitis B
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These findings suggest that the polymorphic variant of IFNA1 (-2) gene is associated with chronic HBV infection, and high expression levels of the IFNAR1 gene and low levels of IFNA1 might contribute to the pathogenesis of chronic infection in these subjects.
|
27101083 |
2015 |
|
melanoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
RNA expression of 65 melanoma cell lines by microarray and selected lines with known IFN responsiveness showed significant inverse correlations between STAT1/REST that were related to cellular responses to IFN.
|
23598529 |
2013 |
|
melanoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of IFNα and IFNβ in B16 cells efficiently suppressed the establishment of inoculated melanoma.
|
23018621 |
2012 |
|
melanoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We examined the effects of anti-human CYR61 monoclonal antibody on proliferation and evaluated the changes in CYR61 expression and cell proliferation in response to treatment with either epirubicin or interferon (IFN)-α. CYR61 was expressed at lower levels in patients with malignant melanoma than in patients with other skin tumors or with no pathology.
|
27665942 |
2016 |
|
melanoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The antiproliferative, pro-apoptotic and immunomodulatory activity of BRAF-I and IFNα combination was tested in vitro and in vivo utilizing three melanoma cell lines, HLA class I-MA peptide complex-specific T-cells and immunodeficient mice (5 per group for survival and 10 per group for tumor growth inhibition).All statistical tests were two-sided.
|
26851802 |
2016 |
|
melanoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In the molecularly defined low-risk subgroup, patients treated with high-dose IFN had a significantly improved RFS compared with patients in the other two subgroups (<i>P</i> < 0.05).<b>Conclusions:</b> These results validate the independent impact of combined expression levels of SPP1, RGS1, and NCOA3 on survival of melanoma in a prospectively collected cohort.<i></i>.
|
28790109 |
2017 |
|
melanoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These results show that there is a specific disruption of IFN-alpha gene activation rather than IFN-beta in melanoma lines and suggest that this is due to disruption of a trans-acting IFN-alpha gene transcription factor.
|
7664286 |
1995 |
|
melanoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Evaluation of NOS1 levels in melanomas and IFN responsiveness of purified PBMCs from patients indicated a negative correlation between NOS1 expression in melanomas and the responsiveness of PBMCs to IFN-α.
|
24691438 |
2014 |
|
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Peg-IFN inhibits β-catenin signaling through the up-regulation of RanBP3, which may be a contributory mechanism for the delayed HCC and improved survival in treated HCV patients.
|
21093092 |
2011 |
|
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We found that while HBV replication in transfected human hepatoma Huh-7 cell was severely inhibited by IFN-α treatment as reported previously, this inhibition was markedly impaired in the cell in which the expression of IFN-inducible, double-stranded RNA-dependent protein kinase (PKR) was stably and specifically suppressed through RNA-interference.
|
21710204 |
2011 |
|
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Type I IFN receptor type 2 (IFNAR2) expression correlates significantly with clinical response to interferon (IFN)-alpha/5-fluorouracil (5-FU) combination therapy for hepatocellular carcinoma (HCC).
|
19401692 |
2009 |
|
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of IFN-alpha receptors was found in all 3 HCC cell lines.
|
11172336 |
2001 |
|
Malignant neoplasm of pancreas
|
0.360 |
AlteredExpression
|
disease |
BEFREE |
Therefore, we examined transfection of the human pancreatic cancer cell line DAN-G with a retrovirus encoding for IFN-alpha and the effect of IFN-alpha gene expression alone or in combination with gemcitabine on growth inhibition of DAN-G pancreatic cancer cells in vitro and in vivo in orthotopically implanted DAN-G cells in nude mice.
|
15320962 |
2004 |